TetraSOD® EXTRACT

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Skin Care: Antioxidant SOD-rich Extract

TetraSOD^® is the key to our dermocosmetic formula and the secret of a powerful antioxidant treatment with extraordinary results for skin care and anti-ageing.

Natural dermocosmetic extract based on bioactive compounds: peptides, β-glucans, polysaccharides, vitamins (B12, C, E), carotenoids such as β-carotene, omega-3 fatty acids and the enzyme with the highest known antioxidant activity, SOD.

TetraSOD^® Cosmetic Extract

From the water of the Atlantic Ocean, a natural product with unique properties for skin care to fight the oxidizing effects of age is born. In our R&D&i department we have cultivated different microalgae species under controlled conditions to obtain active biomolecules.

Each of the species of microalgae used in our extract has its specific dermocosmetic function, based on bioactive compounds:

TetraSOD^® (the natural compound with the highest antioxidant capacity)
vitamins (B12, C, E)
β-carotene
essential peptides
β-glucans
polysaccharides
Omega 3 fatty acids

This broad spectrum of bioactive compounds allows us to regulate over 10 different skin metabolic processes with our unique natural product. There may be other algae extracts on the market, but none with the bioactivity of the TetraSOD^® EXTRACT.

In the R&D&i Department of Fitoplancton Marino, the team has developed a gene expression platform as a genomic tool to measure more than 500 genes that show improvements in different activities:

anti-inflammatory capacity
collagen promoters
hydration
cell division
cell regeneration
immune function

Once the activity has been tested in vitro, we always test it in our formulations, and only the highest performing ones are made into products for dermocosmetic and therapeutic skin applications. The purpose of the following study was to determine the expression of specific genes in fibroblast cells treated with TetraSOD^® EXTRACT.

Dermocosmetic properties

TetraSOD^® EXTRACT includes a wide range of dermocosmetic properties of great interest based on both in vitro and in vivo results:

sod extract cream bioactive capacities and properties

1. Skin care and protection

TetraSOD^® EXTRACT provides maximum antioxidant protection to skin cells, suppressing the effects of H2O2-induced oxidative stress on cell viability by up to 70%. Reduces inflammatory processes, dermatitis and dryness. Improves the severity of lesions, skin xerosis and itching in patients with psoriasis, seborrheic and atopic dermatitis, rosacea and intolerant skins.

2. Anti-inflammatory properties

TetraSOD^® EXRACT protects human fibroblasts from inflammation by inhibiting the expression of the gene IL-1R. In addition, it provides a significant improvement in skin disorders such as psoriasis or seborrheic and atopic dermatitis (90% disappearance of itching or pruritus, 85% reduction in the severity of lesions).

3. Increase in cell proliferation and angiogenesis

TetraSOD^® EXTRACT promotes cell proliferation activity as it increases intracellular ATP levels by up to 50%, improving cell proliferation and skin cell regeneration. In addition, TetraSOD® EXTRACT enhances angiogenesis through the VEGF-A and HGF pathways.

4. Apoptosis pathway modulator

TetraSOD^® EXTRACT protects cells from entering apoptosis in accordance with the transcriptional up-regulation of HSBP1.

5. Anti-wrinkle effect

TetraSOD^® EXTRACT possesses anti-wrinkle activity based on the suppression of elastase activity and the up-regulation of FBN1 and CRABP2.

6. Improvement of age spots and pigmentation

TetraSOD^® EXTRACT inhibits tyrosinase, the rate-limiting step in melanin production in melanocytic skin cells, a therapeutic way to treat age spots.

7. Wound healing

TetraSOD^® EXTRACT enhances wound healing through the VEGF-A, COL6A1 and HGF pathways.

8. Skin hydration

TetraSOD^® EXTRACT offers increased skin hydration through AQP3, a water and glycerol transporter involved in skin physiology.

9. Anti-cellulite activity

TetraSOD^® EXTRACT presents an anti-cellulite effect by up-regulating the expression of KLF2.

Cosmetic applications

TetraSOD^® EXTRACT can be used in a variety of cosmetic products. It can also be incorporated into creams where immediate and long-lasting hydration is needed, such as targeted treatments for especially dry skin. TetraSOD^® EXTRACT is a collagen promoter and skin brightener. It has a high antioxidant capacity and a high content of natural hydration factors that help repair the skin and thus contribute to restoring the natural barrier against external factors. Thanks to its antioxidant, anti-wrinkle and regenerative capacity, it is also suitable for serums or treatments that seek a rapid reduction of wrinkles. All these properties help combat premature ageing and reduce skin flaking caused by different processes such as psoriasis, seborrheic and atopic dermatitis, and rosacea. For that reason, it can be incorporated into formulations for atopic dermatitis and other skin disorders. Finally, its high vitamin B12 content makes it suitable for creams and treatments for skin hyperpigmentation and vitiligo.

TetraSOD^® EXTRACT: Marine Origin Biotechnological Innovation

The ocean provides many unique environments and rich resources, and a myriad of marine organisms exist with great potential to produce bioactive compounds that can be used as nutraceuticals and cosmeceuticals. The origin of marine phytoplankton (microalgae) dates back 2.5 billion years. These organisms were responsible for the production of oxygen that turned the atmosphere of our planet into a “breathable” environment thus allowing the development of other forms of life. Today, marine phytoplankton produces 50% of the oxygen we breathe. These organisms have adapted to extremely harsh and competitive environments by producing a number of compounds and secondary metabolites for chemical defense, and are therefore able to live in a wide range of ecological niches. For example, microalgae have developed survival strategies based on the synthesis of antioxidant and highly protective compounds that represent a natural barrier against external agents. Fitoplancton Marino innovates with a process adjusted under specific conditions to develop and produce ingredients of marine origin focused on improving the quality of life of people who are aware of the benefits of nutraceutical and dermocosmetic products for their health. As an extension of its portfolio, Fitoplancton Marino has launched a unique, highly purified extract with high bioactive capacity and has developed a methodology to scientifically test and prove TetraSOD^® EXTRACT for dermocosmetic applications. Now, with TetraSOD^® EXTRACT, we can take full advantage of the same bioactive compounds that these organisms use. Based on a solid R&D activity, which includes both in vitro and in vivo research, Fitoplancton Marino laboratories capture active ingredients from the ocean for both therapeutic and anti-ageing cosmetics to protect and maintain a healthy skin, enhancing the natural processes of repair, regeneration, and hydration.